Chemical carcinogens generally require metabolic conversion to some form of "ultimate" carcinogen . 化学致癌物一般需要通过代谢来转换成某种形式的“最终”致癌物。
A variety of chemical carcinogens as diverse as benzene , cigarette smoke , and nitrites can initiate and / or promote this process 多种多样的化学致癌物如苯、吸烟、亚硝酸盐都能够引起(和)或促进肿瘤的发生。
Chemical carcinogens can cause modifications or damages on dna directly . if these damages are not repaired properly , they result in mutagenesis and carcinogenesis 化学致癌物能直接在dna上造成修饰和损伤:如果没有被正确修复,这些损伤将导致突变的形成。
Therefore , it is important to study the profiles of gene expression , which will help understand the global cellular stress responses to chemical carcinogens , and further elucidate the mechanisms of nontargeted mutagenesis 所以,从整体上研究烷化剂作用后细胞基因表达谱改变,对于了解化学致癌物诱发的哺乳动物细胞应激反应的全貌和揭示非定标性突变的发生机制具有非常重要的意义。
Think now , undesirable disposition sends cancer to adopt 3 approaches : it is to promote cancer cell to grow ; the 2 immune force that are scathing airframe ; the 3 active that are enzymatic department of change airframe small system , affect the change of other and chemical carcinogen 现认为,不良性格致癌通过三条途径:一是促进癌细胞生长;二是损伤机体的免疫力;三是改变机体微体酶系的活性,影响其他化学致癌物质的转变。